NFL Week 2 2026: Full Schedule, Odds and Kickoff Times

The Miami Dolphins are 12.5-point underdogs on the road at San Francisco, the widest spread on the NFL Week 2 2026 schedule, while the Los Angeles Rams are favored by a touchdown at home in the Monday night finale. Sixteen games run from Thursday, Sept. 17 through Monday, Sept. 21, and the full NFL Week 2 schedule and odds board is set at every book.

NFL Week 2 2026 schedule: every game and kickoff time

Thursday, Sept. 17

Detroit Lions at Buffalo Bills, 8:15 PM ET, Prime Video

Sunday, Sept. 20, 1:00 PM ET

Carolina Panthers at Atlanta Falcons (FOX)

New Orleans Saints at Baltimore Ravens (CBS)

Minnesota Vikings at Chicago Bears (FOX)

Cincinnati Bengals at Houston Texans (CBS)

Pittsburgh Steelers at New England Patriots (CBS)

Green Bay Packers at New York Jets (FOX)

Cleveland Browns at Tampa Bay Buccaneers (CBS)

Philadelphia Eagles at Tennessee Titans (FOX)

Sunday, Sept. 20, 4:05 PM ET

Jacksonville Jaguars at Denver Broncos (CBS)

Las Vegas Raiders at Los Angeles Chargers (CBS)

Sunday, Sept. 20, 4:25 PM ET

Seattle Seahawks at Arizona Cardinals (FOX)

Washington Commanders at Dallas Cowboys (FOX)

Miami Dolphins at San Francisco 49ers (FOX)

Sunday, Sept. 20, 8:20 PM ET

Indianapolis Colts at Kansas City Chiefs (NBC)

Monday, Sept. 21, 8:15 PM ET

New York Giants at Los Angeles Rams (ESPN)

NFL Week 2 odds: the full board

Lines below are DraftKings numbers as of this writing and will move before kickoff.

Lions at Bills: Bills -3.5, Lions +154 / Bills -185 moneyline, total 53.5

Vikings at Bears: Bears -5.5, Vikings +205 / Bears -250, total 49.5

Browns at Buccaneers: Buccaneers -8.5, Browns +295 / Bucs -375, total 40.5

Eagles at Titans: Eagles -7, Eagles -310 / Titans +250, total 40.5

Panthers at Falcons: Panthers -1.5, Panthers -125 / Falcons +110, total 43.5

Packers at Jets: Packers -4.5, Packers -225 / Jets +185, total 44.5

Steelers at Patriots: Patriots -5.5, Steelers +195 / Patriots -238, total 41.5

Saints at Ravens: Ravens -8.5, Saints +295 / Ravens -375, total 47.5

Bengals at Texans: Texans -3, Bengals +124 / Texans -148, total 46.5

Raiders at Chargers: Chargers -7, Raiders +235 / Chargers -290, total 44.5

Jaguars at Broncos: Broncos -2.5, Jaguars +124 / Broncos -148, total 43.5

Dolphins at 49ers: 49ers -12.5, Dolphins +600 / 49ers -900, total 46.5

Seahawks at Cardinals: Seahawks -4.5, Seahawks -225 / Cardinals +185, total 41.5

Commanders at Cowboys: Cowboys -3.5, Commanders +164 / Cowboys -198, total 50.5

Colts at Chiefs: Chiefs -6.5, Colts +235 / Chiefs -290, total 48.5

Giants at Rams: Rams -7, Giants +275 / Rams -345, total 48.5

Six of the sixteen games carry a spread of a touchdown or more, which is a heavier-chalk week than usual for a Week 2 slate, before injury reports have had much chance to separate the good teams from the merely undefeated.

Betting and DFS impact

The Dolphins-49ers line is the outlier of the board. A 12.5-point spread with a +600 moneyline on the road side is a number built for teasers and same-game parlays rather than a straight spread play, and it is the only game on the board with a double-digit spread. The Panthers-Falcons game carries the smallest spread on the board at 1.5 points, which makes it the most attractive game for anyone shopping a moneyline dog rather than laying points.

The Monday night closer between the Giants and Rams doubles as the first home game for Los Angeles without reigning Defensive Player of the Year Myles Garrett, who had knee surgery this week and is out at minimum through Week 5. StatSniper's Myles Garrett injury breakdown covers what his absence does to the Rams' pass rush and how it lands on the DPOY market, and it is worth checking before betting the Rams' team total or any Los Angeles defensive props for this game.

The 8.5-point favorites, Buccaneers over Browns and Ravens over Saints, are the two largest home chalk numbers outside the Dolphins game, and both totals sit under 48, which points the model toward game-script blowout scripts rather than shootouts. Chiefs -6.5 at home over the Colts is the primetime number most likely to move before Sunday night as the week's injury reports come in.

See our AI sports picks hub for the model's full slate of Week 2 picks once injury reports are final, and StatSniper's NFL Week 1 schedule recap has the opening-week results these lines are built on.

What to watch next

Injury reports land Wednesday and Thursday and will move several of these numbers, especially the Dolphins-49ers total and the Rams' number against the Giants. The Thursday night Lions-Bills opener sets the tone for the week's line movement, and any Friday-morning report on a Sunday starting quarterback is the single biggest swing factor left on the board.

FAQ

What time is the Lions vs. Bills game in Week 2? Thursday, Sept. 17 at 8:15 PM ET on Prime Video.

Who are the biggest underdogs in NFL Week 2 2026? The Miami Dolphins, at 12.5 points and +600 on the moneyline at San Francisco, the widest number on the Week 2 board.

What time is the Giants vs. Rams Monday night game? Monday, Sept. 21 at 8:15 PM ET on ESPN. The Rams are 7-point home favorites and playing their first home game since Myles Garrett's knee surgery.

Which NFL Week 2 game has the closest spread? Panthers at Falcons, with Carolina favored by just 1.5 points, the smallest number on the board.

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