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San Francisco 49ers vs Arizona Cardinals

San Francisco 49ersSF
Sun, Jan 1012:00 AM EST
Arizona CardinalsARI

State Farm Stadium · Glendale

Team Season Averages

San Francisco 49ersLeads 8 of 9
vs
Arizona CardinalsLeads 1 of 9

Offense

  • 29.4Points per game19.8
  • 376.8Total yards per game318.0
  • 241.5Passing yards per game215.3
  • 135.3Rushing yards per game102.7

Defense

  • 19.5Points allowed per game28.3
  • 291.9Yards allowed per game337.3

Efficiency

  • 51.7%Third-down conversion rate38.0%
  • 84.6%Red-zone scoring rate42.9%
  • 1.4Turnovers per game0.9

Highlighted values lead the matchup; for points allowed, turnovers and similar stats, lower is better.

Odds

SportsbookSpread (ARI)TotalSF MLARI ML
DDraftKings+8.544.5-410+320
BBetus+8.544.5——

San Francisco 49ers vs Arizona Cardinals Projected Starting Lineups

Official starters post at kickoff. Projections repeat each team's last starting lineup, with this week's injury statuses marked.

San Francisco 49ers

Projected starters, based on SF's Week 9 lineup

Arizona Cardinals

Projected starters, based on ARI's Week 9 lineup

Player props

San Francisco 49ers vs Arizona Cardinals Player Props

Prop lines and results for the players in this game, by market.

League-wide markets: NFL Receiving Yards props · NFL Receptions props · NFL Rushing Yards props · NFL Passing Yards props · NFL Passing Touchdowns props · NFL Kicking Points props

San Francisco 49ers vs Arizona Cardinals: Matchup Preview

The San Francisco 49ers (7-1) visit the Arizona Cardinals (3-6) in this NFL game, which kicks off on Sunday, January 10, 2027 at 12:00 AM ET at State Farm Stadium, Glendale.

Team pages: San Francisco 49ers · Arizona Cardinals

San Francisco 49ers vs Arizona Cardinals Odds

DraftKings lists the Arizona Cardinals at ARI +8.5 on the spread, with the total set at 44.5. Moneylines are San Francisco 49ers -410 and Arizona Cardinals +320. Lines move up to game time; the odds table above compares every book we track so you can shop the number.

See the full NFL odds board and the NFL schedule. Looking for a side rather than a line? See today's NFL picks. For the model's reasoning, read our AI NFL predictions.

San Francisco 49ers vs Arizona Cardinals — Common Questions

When do the San Francisco 49ers play the Arizona Cardinals?+

San Francisco 49ers at Arizona Cardinals kicks off on Sunday, January 10, 2027 at 12:00 AM ET at State Farm Stadium, Glendale. Times are shown in Eastern Time.

What are the odds for San Francisco 49ers vs Arizona Cardinals?+

DraftKings lists the Arizona Cardinals at ARI +8.5 on the spread, with the total set at 44.5. Moneylines are San Francisco 49ers -410 and Arizona Cardinals +320. Lines move up to game time; the odds table above compares every book we track so you can shop the number.

Where is San Francisco 49ers vs Arizona Cardinals being played?+

The game is at State Farm Stadium, Glendale.

Where can I follow the San Francisco 49ers vs Arizona Cardinals live score?+

This page carries the live score, the period-by-period line score, and the box score while the game is on, then the final result and full stats once it ends.

Is Stat Sniper a sportsbook?+

No. Stat Sniper does not accept wagers or hold funds. The scores, odds, and stats on this page are reference data — any bet you place happens at the sportsbook of your choice.

More NFL Week 18 predictions: NFL Week 18 best bets and the Week 18 schedule.

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San Francisco 49ers vs Arizona Cardinals AI Sports Picks & Predictions