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Arizona Cardinals vs San Francisco 49ers

Arizona CardinalsARI
Sun, Sep 278:05 PM UTC
San Francisco 49ersSF

Levi's Stadium · Unknown

Team Season Average

ARISF

Offense

—
PPG
27.0
—
YDS/G
379.0
—
PASS/G
205.0
—
RUSH/G
174.0

Defense

—
OPP PPG
7.0
—
OPP YDS
290.0

Efficiency

—
3RD %
58.3%
—
RZ %
66.7%
—
TO/G
1.0

Odds

SportsbookSpread (SF)TotalARI MLSF ML
DDraftKings-8.547.5+340-440
FFanDuel-8.547.5+350-450
BBetMGM-848+320-425
CCaesars-847.5+325-410
BBetOnline-948+316-400
BBetRivers-848+335-455
BBetus-948+320-400
BBovada-848+295-390
FFanatics-848+310-400
LLowVig-8.548+316-400
MMyBookie-8.548+310-420

Arizona Cardinals vs San Francisco 49ers: Matchup Preview

The Arizona Cardinals (0-0) visit the San Francisco 49ers (1-0) in this NFL game, which kicks off on Sunday, September 27, 2026 at 4:05 PM ET at Levi's Stadium, Unknown. The Arizona Cardinals come in with 6 days of rest; the San Francisco 49ers have 6 days of rest.

Team pages: Arizona Cardinals · San Francisco 49ers

Arizona Cardinals vs San Francisco 49ers Odds

DraftKings lists the San Francisco 49ers at SF -8.5 on the spread, with the total set at 47.5. Moneylines are Arizona Cardinals +340 and San Francisco 49ers -440. Lines move up to game time; the odds table above compares every book we track so you can shop the number.

See the full NFL odds board and the NFL schedule. Looking for a side rather than a line? See today's NFL picks. For the model's reasoning, read our AI NFL predictions.

Arizona Cardinals vs San Francisco 49ers— Common Questions

When do the Arizona Cardinals play the San Francisco 49ers?+

Arizona Cardinals at San Francisco 49ers kicks off on Sunday, September 27, 2026 at 4:05 PM ET at Levi's Stadium, Unknown. Times are shown in Eastern Time.

What are the odds for Arizona Cardinals vs San Francisco 49ers?+

DraftKings lists the San Francisco 49ers at SF -8.5 on the spread, with the total set at 47.5. Moneylines are Arizona Cardinals +340 and San Francisco 49ers -440. Lines move up to game time; the odds table above compares every book we track so you can shop the number.

Where is Arizona Cardinals vs San Francisco 49ers being played?+

The game is at Levi's Stadium, Unknown.

Where can I follow the Arizona Cardinals vs San Francisco 49ers live score?+

This page carries the live score, the period-by-period line score, and the box score while the game is on, then the final result and full stats once it ends.

Is Stat Sniper a sportsbook?+

No. Stat Sniper does not accept wagers or hold funds. The scores, odds, and stats on this page are reference data — any bet you place happens at the sportsbook of your choice.