Back to NFL
NFL

Denver Broncos vs San Francisco 49ers

Denver BroncosDEN
Sun, Oct 48:25 PM UTC
San Francisco 49ersSF

Levi's Stadium · Unknown

Team Season Average

DENSF

Offense

—
PPG
27.0
—
YDS/G
379.0
—
PASS/G
205.0
—
RUSH/G
174.0

Defense

—
OPP PPG
7.0
—
OPP YDS
290.0

Efficiency

—
3RD %
58.3%
—
RZ %
66.7%
—
TO/G
1.0

Odds

SportsbookSpread (SF)TotalDEN MLSF ML
DDraftKings-345.5+145-175
FFanDuel-346.5+124-146
CCaesars-345.5+135-159
BBetOnline-346——
BBetRivers-346+128-155
BBetus-346——
LLowVig-346——
MMyBookie-346+123-158

Denver Broncos vs San Francisco 49ers: Matchup Preview

The Denver Broncos (0-0) visit the San Francisco 49ers (1-0) in this NFL game, which kicks off on Sunday, October 4, 2026 at 4:25 PM ET at Levi's Stadium, Unknown.

Team pages: Denver Broncos · San Francisco 49ers

Denver Broncos vs San Francisco 49ers Odds

DraftKings lists the San Francisco 49ers at SF -3 on the spread, with the total set at 45.5. Moneylines are Denver Broncos +145 and San Francisco 49ers -175. Lines move up to game time; the odds table above compares every book we track so you can shop the number.

See the full NFL odds board and the NFL schedule. Looking for a side rather than a line? See today's NFL picks. For the model's reasoning, read our AI NFL predictions.

Denver Broncos vs San Francisco 49ers— Common Questions

When do the Denver Broncos play the San Francisco 49ers?+

Denver Broncos at San Francisco 49ers kicks off on Sunday, October 4, 2026 at 4:25 PM ET at Levi's Stadium, Unknown. Times are shown in Eastern Time.

What are the odds for Denver Broncos vs San Francisco 49ers?+

DraftKings lists the San Francisco 49ers at SF -3 on the spread, with the total set at 45.5. Moneylines are Denver Broncos +145 and San Francisco 49ers -175. Lines move up to game time; the odds table above compares every book we track so you can shop the number.

Where is Denver Broncos vs San Francisco 49ers being played?+

The game is at Levi's Stadium, Unknown.

Where can I follow the Denver Broncos vs San Francisco 49ers live score?+

This page carries the live score, the period-by-period line score, and the box score while the game is on, then the final result and full stats once it ends.

Is Stat Sniper a sportsbook?+

No. Stat Sniper does not accept wagers or hold funds. The scores, odds, and stats on this page are reference data — any bet you place happens at the sportsbook of your choice.