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NFL

San Francisco 49ers vs Buffalo Bills

Highmark Stadium

Team Season Averages

San Francisco 49ersLeads 5 of 9
vs
Buffalo BillsLeads 4 of 9

Offense

  • 23.6Points per game29.1
  • 384.5Total yards per game345.3
  • 246.2Passing yards per game226.1
  • 138.4Rushing yards per game119.2

Defense

  • 23.6Points allowed per game19.5
  • 304.3Yards allowed per game329.1

Efficiency

  • 44.2%Third-down conversion rate42.0%
  • 50.0%Red-zone scoring rate63.8%
  • 1.5Turnovers per game0.6

Highlighted values lead the matchup; for points allowed, turnovers and similar stats, lower is better.

Odds

SportsbookSpread (BUF)TotalSF MLBUF ML
DDraftKings-6.545+270-340
FFanDuel-6.544.5+250-310
BBetMGM-6.545+260-350
CCaesars-6.545+275-350
BBetOnline-6.545+268-318
BBetRivers-6.545+240-305
BBetus-6.545+255-310
BBovada-6.545+255-310
LLowVig-6.545+268-318
MMyBookie-6.545+250-320

San Francisco 49ers vs Buffalo Bills: Final Score & Recap

The Buffalo Bills beat the San Francisco 49ers 35-10 in this NFL game at Highmark Stadium on Sunday, December 1, 2024. The line score, team and player box scores, and scoring summary are in the Game Stats tab.

Team pages: San Francisco 49ers · Buffalo Bills

San Francisco 49ers vs Buffalo Bills Odds

DraftKings lists the Buffalo Bills at BUF -6.5 on the spread, with the total set at 45. Moneylines are San Francisco 49ers +270 and Buffalo Bills -340. Those are the closing numbers; the odds table above compares every book we track.

See the full NFL odds board and the NFL schedule. Looking for a side rather than a line? See today's NFL picks. For the model's reasoning, read our AI NFL predictions.

San Francisco 49ers vs Buffalo Bills — Common Questions

Who won San Francisco 49ers vs Buffalo Bills?+

The Buffalo Bills beat the San Francisco 49ers 35-10 on Dec 1, 2024 at Highmark Stadium. The full box score and line score are on this page.

What are the odds for San Francisco 49ers vs Buffalo Bills?+

DraftKings lists the Buffalo Bills at BUF -6.5 on the spread, with the total set at 45. Moneylines are San Francisco 49ers +270 and Buffalo Bills -340. Those are the closing numbers; the odds table above compares every book we track.

Where was San Francisco 49ers vs Buffalo Bills played?+

The game was at Highmark Stadium.

Is Stat Sniper a sportsbook?+

No. Stat Sniper does not accept wagers or hold funds. The scores, odds, and stats on this page are reference data — any bet you place happens at the sportsbook of your choice.