Houston Astros vs Cleveland Guardians AI Sports Picks & Predictions

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MLB

Houston AstrosHOU

5–8

Final

Cleveland GuardiansCLE

Progressive Field

Team Season Averages

Houston AstrosLeads 8 of 18

Cleveland GuardiansLeads 10 of 18

Batting

5.42Runs per game4.04
0.259Batting average0.227
0.349On-base percentage0.314
0.439Slugging percentage0.378
0.788OPS0.693
1.25Home runs per game1.04
8.83Hits per game7.33
30Home runs25
12Stolen bases18

Pitching

5.93ERA4.09
1.62WHIP1.27
9.81Strikeouts per nine9.93
5.55Walks per nine3.75
5.75Runs allowed per game4.00
0.262Opponent batting average0.228
228Pitching strikeouts233
3Quality starts8
5Saves7

Highlighted values lead the matchup; for points allowed, turnovers and similar stats, lower is better.

Odds

Sportsbook	Spread (CLE)	Total	HOU ML	CLE ML
DDraftKings	-1.5	8.5	+129	-156
FFanDuel	-1.5	8.5	+130	-154
BBetMGM	-1.5	8.5	+130	-155
CCaesars	-1.5	8.5	+130	-155
BBetOnline	-1.5	8.5	+132	-146
BBetRivers	-1.5	8.5	+123	-152
BBetus	-1.5	9	+131	-146
BBovada	-1.5	8.5	+132	-158
FFanatics	-1.5	9	+130	-155
LLowVig	-1.5	8.5	+132	-146
MMyBookie	-1.5	9	+132	-156

Game Information

Progressive Field

Stadium

Apr 21, 2026

6:10 PM EDT

Gametime weather

Conditions pending

Lineups

HOU

Starters

CLE

Starters

Rankings

Team	Offense	Defense
HOU	4th	29th
CLE	21st	12th

Matchup

HOUCLE

9-15Record13-11
37.5%Win %54.2%
7-6Home record7-4
2-9Road record6-7
3-7Last 105-5
1Streak-1
-12Run diff-7
3-8Division2-1
1 (B2B)Rest days1 (B2B)

Scores

Team	1	2	3	4	5	6	7	8	9	T
HOU	0	0	0	0	3	0	1	0	1	5
CLE	1	1	0	0	0	0	0	6	—	8

Team Stats

HOUStatCLE

5Runs8
10Hits11
0Errors1
0Home runs1
5RBI8
0Stolen bases1
5K (bat)7
7K (pit)5
8BB (pit)3

Player Stats

HOU — Batting

Player	AB	R	H	RBI	BB
Jose Altuve2B	5	0	0	0	0
Yordan AlvarezLF	5	0	2	3	0
Cam Smith3B	4	1	2	0	0
Yainer DiazC	4	1	1	0	0
Carlos CorreaSS	4	0	2	1	1
Christian Walker1B	4	0	0	0	0
Isaac Paredes3B	3	1	1	0	1
Brice MatthewsSS	3	1	2	1	0
Dustin HarrisCF	1	1	0	0	0
Daniel JohnsonCF	0	0	0	0	1

HOU — Pitching

Player	IP	H	R	ER	BB	K
Ryan WeissRP	3.1	5	2	2	4	4
Kai-Wei TengRP	2.2	0	0	0	1	2
Colton GordonSP	1.0	2	0	0	0	1
Bryan KingRP	0.2	2	3	3	2	0
Enyel De Los SantosRP	0.1	2	3	3	1	0

CLE — Batting

Player	AB	R	H	HR	RBI	BB
George ValeraRF	5	0	1	0	1	0
Kyle Manzardo1B	4	0	2	0	2	1
Angel MartinezCF	4	2	2	1	1	0
Brayan RocchioSS	4	1	1	0	1	0
Chase DeLauterRF	4	1	1	0	3	1
Steven KwanLF	3	1	1	0	0	2
Jose Ramirez3B	3	2	1	0	0	2
Bo NaylorC	2	0	0	0	0	0
Austin HedgesC	2	0	1	0	0	0
Daniel SchneemannSS	2	1	1	0	0	2

CLE — Pitching

Player	IP	H	R	ER	BB	K
Parker MessickSP	5.0	6	3	3	1	4
Cade SmithRP	1.0	2	1	1	1	1
Peyton PalletteRP	1.0	0	0	0	1	0
Shawn ArmstrongRP	1.0	0	0	0	0	0
Tim HerrinRP	0.2	1	0	0	0	0
Connor BrogdonRP	0.1	1	1	0	0	0

Scoring Summary

95 events · 9 scoring

Inning 1 Top

Top
Correa struck out looking.
0-0
Top
Alvarez grounded out to shortstop.
0-0
Top
Altuve struck out swinging.
0-0

Inning 1 Bottom

Bottom
Kwan grounded out to first.
0-0
Bottom
DeLauter grounded out to pitcher.
0-0
Bottom
Ramírez singled to right.
0-0
Bottom
Manzardo walked, Ramírez to second.
0-0
Bottom
Valera singled to left, Ramírez scored, Manzardo to second.
0-1
Bottom
Schneemann struck out swinging.
0-1

Inning 2 Top

Top
Walker grounded out to shortstop.
0-1
Top
Paredes grounded out to shortstop.
0-1
Top
Smith singled to right.
0-1
Top
Smith picked off first.
0-1

Inning 2 Bottom

Bottom
Martínez homered to right center (399 feet).
0-2
Bottom
Hedges struck out swinging.
0-2
Bottom
Rocchio grounded out to shortstop.
0-2
Bottom
Kwan walked.
0-2
Bottom
DeLauter walked, Kwan to second.
0-2
Bottom
Ramírez grounded out to first.
0-2

Inning 3 Top

Top
Diaz grounded out to second.
0-2
Top
Matthews struck out swinging.
0-2
Top
Harris grounded out to second.
0-2

Inning 3 Bottom

Bottom
Manzardo flied out to left.
0-2
Bottom
Valera popped out to shortstop.
0-2
Bottom
Schneemann walked.
0-2
Bottom
Martínez struck out swinging.
0-2

Inning 4 Top

Top
Correa singled to right.
0-2
Top
Alvarez flied out to center.
0-2
Top
Altuve flied out to center.
0-2
Top
Walker flied out to center.
0-2

Inning 4 Bottom

Bottom
Hedges singled to right.
0-2
Bottom
Rocchio struck out swinging.
0-2
Bottom
Kwan singled to right, Hedges to second.
0-2
Bottom
Gordon relieved Weiss
0-2
Bottom
DeLauter popped out to shortstop.
0-2
Bottom
Ramírez flied out to center.
0-2

Inning 5 Top

Top
Paredes singled to left.
0-2
Top
Smith struck out swinging.
0-2
Top
Diaz doubled to right, Paredes to third.
0-2
Top
Matthews singled to center, Paredes scored, Matthews out stretching at second, Diaz to third.
1-2
Top
Harris hit by pitch.
1-2
Top
Correa walked, Harris to second.
1-2
Top
Alvarez singled to left, Diaz scored and Harris scored, Alvarez out stretching at second, Correa to third.
3-2

Inning 5 Bottom

Bottom
Matthews in left field.
2-2
Bottom
D. Johnson in center field.
2-2
Bottom
Manzardo singled to right.
3-2
Bottom
Valera struck out looking.
3-2
Bottom
Schneemann singled to left, Manzardo to second.
3-2
Bottom
Teng relieved Gordon
3-2
Bottom
Martínez struck out looking.
3-2
Bottom
Naylor hit for Hedges
3-2
Bottom
Naylor struck out swinging.
3-2

Inning 6 Top

Top
Naylor catching.
3-2
Top
Armstrong relieved Messick
3-2
Top
Altuve grounded out to shortstop.
3-2
Top
Walker grounded out to third.
3-2
Top
Paredes grounded out to first.
3-2

Inning 6 Bottom

Bottom
Rocchio grounded out to first.
3-2
Bottom
Kwan flied out to left.
3-2
Bottom
DeLauter grounded out to first.
3-2

Inning 7 Top

Top
Brogdon relieved Armstrong
3-2
Top
Smith reached on infield single to second.
3-2
Top
Diaz grounded into fielder's choice to third, Smith safe at second on fielding error by third baseman Ramírez.
3-2
Top
Matthews hit sacrifice bunt to third, Diaz to second, Smith to third.
3-2
Top
Herrin relieved Brogdon
3-2
Top
D. Johnson hit by pitch.
3-2
Top
Correa reached on infield single to second, Smith scored, D. Johnson to second, Diaz to third.
4-2
Top
Alvarez flied out to right.
4-2
Top
Altuve grounded into fielder's choice to third, Correa out at second.
4-2

Inning 7 Bottom

Bottom
Ramírez walked.
4-2
Bottom
Manzardo grounded into double play, second to shortstop to first, Ramírez out at second.
4-2
Bottom
Valera grounded out to first.
4-2

Inning 8 Top

Top
Pallette relieved Herrin
4-2
Top
Walker popped out to second.
4-2
Top
Paredes walked.
4-2
Top
Smith popped out to second.
4-2
Top
Diaz grounded into fielder's choice to shortstop, Paredes out at second.
4-2

Inning 8 Bottom

Bottom
De Los Santos relieved Teng
4-2
Bottom
Schneemann walked.
4-2
Bottom
Martínez reached on infield single to third, Schneemann to second.
4-2
Bottom
Naylor popped out to first.
4-2
Bottom
Rocchio singled to center, Schneemann scored, Martínez to second.
4-3
Bottom
King relieved De Los Santos
4-3
Bottom
Kwan walked, Rocchio to second, Martínez to third.
4-3
Bottom
DeLauter tripled to left, Martínez scored, Rocchio scored and Kwan scored.
4-6
Bottom
Ramírez intentionally walked.
4-6
Bottom
Ramírez stole second.
4-6
Bottom
Manzardo singled to right, DeLauter scored and Ramírez scored.
4-8
Bottom
Valera grounded into double play, second to shortstop to first, Manzardo out at second.
4-8

Inning 9 Top

Top
Smith relieved Pallette
4-8
Top
Matthews doubled to center.
4-8
Top
D. Johnson walked.
4-8
Top
Correa grounded into double play, first to shortstop to pitcher, D. Johnson out at second, Matthews to third.
4-8
Top
Alvarez doubled to left, Matthews scored.
5-8
Top
Altuve struck out looking.
5-8

Houston Astros vs Cleveland Guardians AI sports predictions & season series →

Player props

Houston Astros vs Cleveland Guardians Player Props

Prop lines and results for the players in this game, by market.

Carlos Correa
RBIs: 6/22 over · last line 0.5
Carlos Correa RBIs props Carlos Correa Walks props Carlos Correa Hits props
Daulton Varsho
Home Runs: 3/22 over · last line 0.5
Daulton Varsho Home Runs props Daulton Varsho Hits props Daulton Varsho Hits Runs Rbis props
Yainer Diaz
Hits: 12/20 over · last line 0.5
Yainer Diaz Hits props Yainer Diaz Hits Runs Rbis props Yainer Diaz Home Runs props
Christian Vazquez
Hits: 8/17 over · last line 0.5
Christian Vazquez Hits props Christian Vazquez Hits Runs Rbis props Christian Vazquez Home Runs props
Nathaniel Lowe
Home Runs: 1/17 over · last line 0.5
Nathaniel Lowe Home Runs props Nathaniel Lowe RBIs props Nathaniel Lowe Walks props
Rhys Hoskins
Home Runs: 2/17 over · last line 0.5
Rhys Hoskins Home Runs props Rhys Hoskins Hits props Rhys Hoskins RBIs props
Gavin Williams
Strikeouts: 9/16 over · last line 6.5
Gavin Williams Strikeouts props Gavin Williams Hits Allowed props Gavin Williams Outs props
Parker Messick
Hits Allowed: 9/16 over · last line 4.5
Parker Messick Hits Allowed props Parker Messick Strikeouts props Parker Messick Walks props
Hunter Brown
Outs: 6/15 over · last line 15.5
Hunter Brown Outs props Hunter Brown Strikeouts props Hunter Brown Hits Allowed props
Austin Hedges
Home Runs: 2/14 over · last line 0.5
Austin Hedges Home Runs props Austin Hedges Hits Runs Rbis props Austin Hedges Walks props
Peter Lambert
Hits Allowed: 7/14 over · last line 5.5
Peter Lambert Hits Allowed props Peter Lambert Strikeouts props Peter Lambert Outs props
Foster Griffin
Strikeouts: 6/13 over · last line 3.5
Foster Griffin Strikeouts props Foster Griffin ER props Foster Griffin Hits Allowed props

League-wide markets: MLB RBIs props · MLB Walks props · MLB Hits props · MLB Home Runs props · MLB Hits Runs Rbis props · MLB Strikeouts props · MLB Hits Allowed props · MLB Outs props · MLB ER props

Houston Astros vs Cleveland Guardians: Final Score & Recap

The Cleveland Guardians beat the Houston Astros 8-5 in this MLB game at Progressive Field on Tuesday, April 21, 2026. The line score, team and player box scores, and scoring summary are in the Game Stats tab.

Team pages: Houston Astros · Cleveland Guardians

Houston Astros vs Cleveland Guardians Odds

DraftKings lists the Cleveland Guardians at CLE -1.5 on the run line, with the total set at 8.5. Moneylines are Houston Astros +129 and Cleveland Guardians -156. Those are the closing numbers; the odds table above compares every book we track.

See the full MLB odds board and the MLB schedule. Looking for a side rather than a line? See today's MLB picks. For the model's reasoning, read our AI MLB predictions.

Houston Astros vs Cleveland Guardians — Common Questions

Who won Houston Astros vs Cleveland Guardians?+

The Cleveland Guardians beat the Houston Astros 8-5 on Apr 21, 2026 at Progressive Field. The full box score and line score are on this page.

What are the odds for Houston Astros vs Cleveland Guardians?+

Where was Houston Astros vs Cleveland Guardians played?+

The game was at Progressive Field.

Is Stat Sniper a sportsbook?+

No. Stat Sniper does not accept wagers or hold funds. The scores, odds, and stats on this page are reference data — any bet you place happens at the sportsbook of your choice.